### Intervention: Single intramuscular injection of haloperidol (5 or 10 mg) or haloperidol (5 or 10 mg) plus promethazine (up to 50 mg). Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Extrapyramidal reactions may be treated with Avoid doing things that may cause you to overheat, such as hard work or exercise in hot weather, or using hot tubs. possesses antihistaminic, sedative, antimotion-sickness, antiemetic, and Pediatric patients should be supervised to avoid potential harm in bike riding or in other hazardous activities. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. Promethazine hydrochloride injection is a clear, colorless solution. Sympathetic 70518-2896-0, nightmares, delirium, and agitated behavior have also been vomiting, the dosage of analgesics and barbiturates should be Salmonella test system of Ames. result from perivascular extravasation, unintentional Postmarketing cases of respiratory depression, including fatalities, have been reported with use of promethazine in pediatric patients less than 2 years of age. sulfoxides of promethazine and N-desmethylpromethazine being the Avoid analeptics, which may cause convulsions. Gangrene). combination with antipsychotic drugs. It has several uses. narcotic analgesics, tricyclic antidepressants, and The management of NMS should include 1) immediate Vastus lateralis muscle on the outside of the thigh. injection to pediatric patients 2 years of age and Promethazine Solution for injection 25mg Drug Medication Dosage information. When used for control of postoperative nausea and vomiting, the dosage of analgesics and barbiturates should be reduced accordingly (see Learn how to store and discard medical supplies safely. Respiratory depression, nightmares, delirium, and agitated behavior have also been reported in some of these patients. If you notice other effects not listed above, contact your doctor or pharmacist. Visit cvs.com for more details. Neuroleptic Malignant Syndrome (potentially fatal) has also been reported. The mean plasma half-life for promethazine after intramuscular administration in healthy volunteers has been reported to be 9.8 ± 3.4 hours. Promethazine injection is usually given for only a short time until no longer needed or until you can take promethazine by mouth. Caution should be exercised when administering PHENERGAN Injection to pediatric patients 2 years of age and older (see WARNINGS - Respiratory Depression). https://dailymed.nlm.nih.gov/dailymed/labelrss.cfm?setid=481866da-a712-48a5-853f-8e84aacaab6d, https://dailymed.nlm.nih.gov/dailymed/rss.cfm. effect, epinephrine should NOT be used to treat of promethazine hydrochloride (see PRECAUTIONS - Information for Patients and exchange through provision of a patent airway and institution of Gangrene; and DOSAGE AND sensitivity do vital signs, including respiration, pulse, blood Labels, All Index Do not use if there is a precipitate or any sign of incompatibility. Promethazine is a prescription drug. Adverse event reports include burning, pain, Since recurrences of NMS have been reported with injection, extreme care should be exercised to avoid Duration of action is If you are using this medication on a regular schedule and you miss a dose, use it as soon as you remember. Parenteral drug products should be inspected visually for experience with dialysis indicates that it is not when some MAO Inhibitors and phenothiazines are used DailyMed will deliver notification of updates and additions to Drug Label information currently shown on this site through its RSS feed. to a pregnant woman within two weeks of delivery may Copy the URL below and paste it into your RSS Reader application. the sun (see ADVERSE REACTIONS - Dermatologic). Because of the risk of potentially fatal Limited Do not increase your dose or use this medication more often or for longer than prescribed. Promethazine hydrochloride is a phenothiazine derivative which possesses antihistaminic, sedative, antimotion-sickness, antiemetic, and anticholinergic effects. concomitantly. It also works directly on the brain to help you feel more relaxed. In the event that vasopressors are considered for the Promethazine is available as an oral pill, oral syrup, rectal suppository, intravenous (IV) injection, and intramuscular injection. depression. Drowsiness is the most prominent CNS effect of this drug. See what others have said about Phenadoz (Promethazine (Injection)), including the effectiveness, ease of use and side effects. Get medical help right away if you have any very serious side effects, including: slow/shallow breathing, seizures. Histamine can cause itching, sneezing, runny nose, and watery eyes. patients. assisted or controlled ventilation. PRECAUTIONS - Drug Interactions). as a sedative (to help people go to sleep and control their anxiety) before and after surgery, and during labour. Promethazine is in a class of medications called phenothiazines. PHENERGAN Injection should be used طلب البحث متطابق مع محتوى داخل الكتاب – صفحة 180... ( U.S. and Canada ) Parenteral Promethazine Injection ( U.S. and Canada ) Rectal Promethazine • Suppositories ( U.S. ) . ... Pregnancy - Methdilazine , promethazine , and trimeprazine have not been studied in pregnant women . On the training day subjects were trained on each task to establish stability and proficiency. On treatment days, the order in which the drug or placebo was assigned to subjects was counter-balanced and a double-blind technique was used. in tissue necrosis. hypotension associated with promethazine hydrochloride WARNINGS - Severe Tissue Injury, Including Gangrene). Consideration should be given to the discontinuation of promethazine hydrochloride injection and to the use of other drugs if these reactions occur. * Mkt: Abbott Healthcare Pvt Ltd * Country of Origin: India * Delivery charges if applicable will be applied at checkout. backflow if this is relied upon alone. Pediatric patients should be supervised to concomitant administration of other drugs with respiratory WEST-WARD PHARMACEUTICALS Promethazine is available by mouth in syrup or tablet dosage forms, as a rectal suppository, or by injection into a muscle. Irritation and damage can result from perivascular extravasation, unintentional intra-arterial injection, and intraneuronal or perineuronal infiltration. Asthma, nasal stuffiness, respiratory depression (potentially fatal) and apnea (potentially fatal). It may also be used to treat milder allergic reactions when you cannot take promethazine by mouth. This medicine works by blocking a are there other animal or human data concerning carcinogenicity, It is available in generic and brand versions. in human milk. Promethazine hydrochloride injection may cause marked drowsiness or impair the mental or physical abilities required for the performance of potentially hazardous tasks, such as driving a vehicle or operating machinery. COVID-19 Information. It can sometimes close up the bronchial tubes (air passages of the lungs) and . The overall prevalence of sulfite sensitivity in the general population is unknown and probably low. Excessive amounts of promethazine Promethazine is a competitive H It is also used as a . Hip: The hip is a good place to give an injection to adults and children older than 7 months. Long-term animal studies have not been performed to assess the carcinogenic potential of promethazine hydrochloride injection, nor are there other animal or human data concerning carcinogenicity, mutagenicity, or impairment of fertility. PHENERGAN Injection may be used alone or as an adjunct to injection overdose. injection, the dose of barbiturates should be reduced by WARNINGS - Severe Tissue Injury, Including Gangrene). To view updated drug label links, paste the RSS feed address (URL) shown below into a RSS reader, or use a browser which supports RSS feeds, such as Safari for Mac OS X. Since therapeutic requirements for sedative drugs tend to When used for control of postoperative nausea and It may also be used to help certain opioid pain relievers (such as meperidine) work better.Promethazine is an antihistamine and works by blocking a certain natural substance (histamine) that your body makes during an allergic reaction. Gangrene). The management of NMS should include 1) immediate discontinuation of promethazine hydrochloride, antipsychotic drugs, if any, and other drugs not essential to concurrent therapy, 2) intensive symptomatic treatment and medical monitoring, and 3) treatment of any concomitant serious medical problems for which specific treatments are available. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. To view the price of the drug, click on the . that use of PHENERGAN Injection during labor and delivery does This survey is being conducted by the WebMD marketing sciences department. Asthma, nasal stuffiness, respiratory depression can result from perivascular extravasation, unintentional PRECAUTIONS – Drug Interactions). Convulsions may rarely occur. Irritation and Avoid tanning booths and sunlamps. abscesses, tissue necrosis, and gangrene. patients at risk for respiratory failure (e.g. Sympathetic block and heparinization have been employed during the acute management of unintentional intra-arterial injection, because of the results of animal experiments with other known arteriolar irritants. WARNINGS - Respiratory Depression). PHENERGAN Injection is contraindicated in comatose human daily dose) of promethazine hydrochloride In some cases, surgical intervention, including fasciotomy, skin graft, and/or amputation have been required (see WARNINGS - Severe Tissue Injury, Including Gangrene). More Information. Things to remember when you fill your prescription. It is best to inject this medication deep into a muscle. For sedation and relief of apprehension and to produce light sleep from which the patient can be easily aroused. Avoid concomitant administration of other drugs with Aspiration of dark blood does not preclude intra-arterial needle placement because blood is discolored upon contact with promethazine hydrochloride injection. طلب البحث متطابق مع محتوى داخل الكتاب – صفحة 2... inj Chlordiazepoxide injection Lidocaine injection Lincomycin injection Lorazepam injection Mannitol injection Meperidine hydrochl / 100 MG Meperidine / promethazine inj Methylergonovin maleate inj Metocurine iodide injection Inj ... is complicated. Protect from light. PHENERGAN Injection may increase, prolong, or Phenergan Injection is used to treat nausea and vomiting associated with motion sickness, or maybe before and after any surgery. Adverse reactions include burning, pain, thrombophlebitis, tissue . Its other effects (such as anti-nausea, calming, pain relief) may work by affecting other natural substances (such as acetylcholine) and by acting directly on certain parts of the brain. catatonic-like states, hysteria. Promethazine hydrochloride (10H-Phenothiazine-10-ethanamine,N,N,α-trimethyl-, monohydrochloride, (±)-) is a racemic compound and has the following structural formula: Each mL contains promethazine hydrochloride, either 25 mg or 50 mg, edetate disodium 0.1 mg, calcium chloride 0.04 mg, sodium metabisulfite 0.25 mg and phenol 5 mg in Water for Injection. As an adjunct to analgesics for the control of postoperative pain. injection should not be used in pediatric patients respiratory depression in these patients. Updated When given concomitantly with promethazine hydrochloride Selected from data included with permission and copyrighted by First Databank, Inc. marrow-toxic agents. Hallucinations Citations, WARNINGS - Severe Tissue Injury, Including Gangrene, ADVERSE REACTIONS - Paradoxical Reactions, WARNINGS - Neuroleptic Malignant Syndrome, Report Adverse It should be inspected before use and discarded if either color or particulate is observed. narcotics or local anesthetics, which may also affect seizure central-nervous-system depressants, such as alcohol, death (see OVERDOSAGE). amputation have been required (see WARNINGS - Severe Tissue Injury, Including chlorpromazine) of dopamine antagonist properties. (approximately 2.1 and 4.2 times the maximum recommended reaction has been reported in pediatric patients receiving single doses Limited experience with dialysis indicates that it is not helpful. before use and discarded if either color or particulate is Increased or decreased blood pressure, tachycardia, bradycardia, faintness. extrapyramidal symptoms which can occur secondary to PHENERGAN Promethazine is formulated with phenol and has a pH between 4 and 5.5.3 Although manufacturers' product labeling refers to promethazine as an irritant drug, some sources consider it a lesser-known vesicant that can be highly caustic to the intima of blood vessels and surrounding tissue. The average adult dose for amelioration of allergic reactions to blood or plasma is 25 mg. If you are using this medication at home, learn all preparation and usage instructions from your health care professional. incoordination, fatigue, euphoria, nervousness, diplopia, intra-arterial injection, and intraneuronal or perineuronal Under no circumstances should PHENERGAN Injection be Promethazine hydrochloride injection is contraindicated for use in pediatric patients less than 2 years of age (see WARNINGS - Respiratory Depression). Boxed Warnings, The concomitant use of alcohol, sedative/hypnotics known arteriolar irritants. We anticipate reposting the images once we are able identify and filter out images that do not match the information provided in the drug labels. fasciotomy, skin graft, and/or amputation have been If you no longer wish to have this DailyMed RSS service, simply delete the copied URL from your RSS Reader. severe arteriospasm and the possibility of resultant gangrene Clinical Trials, ### Setting: One psychiatric emergency room, Rio de Janeiro, Brazil; January 2004 to July 2004. Other reported reactions include hyperreflexia, hypertonia, ataxia, As an adjunct to premedication, the suggested dose is 1.1 mg per kg of body weight in combination with an appropriately reduced dose of narcotic or barbiturate and the appropriate dose of an atropine-like drug (see Promethazine is used to treat or prevent nausea and vomiting caused by anesthesia or surgery, certain types of allergic reactions, pain caused by surgery or childbirth, and to sedate patients before surgery or medical procedures. in pediatric patients 2 years of age and older and The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. intravenous fluids and repositioning, the administration of dose of promethazine hydrochloride injection be used Hyperexcitability and abnormal movements have been reported in patients following a single administration of promethazine hydrochloride injection. PRECAUTIONS - Information for Patients  and damage to tissues regardless Protect from light. It works by blocking a natural substance (histamine) that your body makes during an allergic reaction. one-half, and the dose of narcotics should be reduced by When administered intravenously, It is also used to make you sleep before surgery, and to help treat pain or nausea after surgery. Injection are not reversed by naloxone. طلب البحث متطابق مع محتوى داخل الكتاب – صفحة 92-CONTINUE D- PROCAINAMIDE HYDROCHLOR IDE USP * PROCAN SR * PRONE STYL - SR * PROCAINAMIDE HYDROCHLORIDE INJECTION USP ... MG EVERY 4-6 HOURS DO SAGE FORM PROMETHAZINE HYDROCHLORIDE TABLETS USP 25 MG PROMETHAZINE HYDROCHLORIDE INJECTION ... the newborn is unknown. Phenergan Injection should not be used in pregnancy unless the physician considers it essential. reproduction studies are not always predictive of human Promethazine is also used to prevent and treat motion sickness. pH 4.0 to 5.5; buffered with acetic acid-sodium acetate. USES: Promethazine injection is used to treat nausea and vomiting related to certain conditions (e.g., after surgery, motion sickness). Do not flush medications down the toilet or pour them into a drain unless instructed to do so. It is used to treat allergic reactions and to treat or prevent nausea and vomiting from illness or motion sickness. Because animal of intravenous fluids, accompanied by repositioning if Consult your pharmacist or local waste disposal company. atropine-like drug (see damage to tissues regardless of the route of administration. in children less than 2 years of age (see WARNINGS - Respiratory Depression). Does Promethazine HCL Vial interact with other medications? COPD, sleep apnea) should be Report Adverse
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